International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies

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:: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies

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ISSN 2228-9860
eISSN 1906-9642
CODEN: ITJEA8


FEATURE PEER-REVIEWED ARTICLE

Vol.12(11) (2021)

  • Preclinical Studies of Microbial Feed Additives on Laboratory Animals

    Alexey Andreevich Boyko, Andrey Georgievich Koshchaev, Yury Andreevich Lysenko, Azamat Khazretovich Shantyz, Albina Vladimirovna Luneva, Anna Alexandrovna Shirina (Federal State Budgetary Educational Institution of Higher Education, Kuban State Agrarian University named after I. T. Trubilin, Kalinina Street 13, Krasnodar, RUSSIA).

    Disciplinary: Veterinary, Zoology, Biotechnology.

    ➤ FullText

    doi: 10.14456/ITJEMAST.2021.218

    Keywords: Preclinical experiment; SBT-Lacto feed additive; Acute toxicity; Chronic toxicity; Irritant effect; Harmlessness; Rats; Pathological effect; Mice; Rabbits.

    Abstract
    The object of research was a microbial feed additive SBT-Lacto, containing a dry culture of lactic acid bacteria: Bifidobacterium lactis (2.5-3.0 %), Lactobacillus acidophilus (2.5-3.0%), Streptococcus thermophilus (2.5-3.0%), Lactobacillus delbrueckii ssp. Bulgaricus (2.5-3.0 %), and fillers: edible citrus fiber (14.0-15.0 %), maltodextrin (76.0-84.0%), to improve the digestibility of mixed feed, increase the safety, growth, and productivity of farm animals, including poultry. The work aimed to determine the acute and chronic toxicity, as well as the irritating effect of the SBT-Lacto feed additive on laboratory animals (mice, rats, rabbits). In the course of research work, clinical, pathoanatomic, biochemical, and morphological studies of the blood of experimental animals were carried out. As a result of the research, it was found that the feed additive SBT-Lacto at a dose of 7500 mg/kg of body weight does not have a toxic effect on the body of laboratory animals. According to the degree of exposure to the body of warm-blooded animals, the feed additive refers to substances that are not very dangerous. The microbial feed additive SBT-Lacto can be recommended for use in practical animal husbandry, including poultry farming.

    Paper ID: 12A11H

    Cite this article:

    Boyko, A. A., Koshchaev, A. G., Lysenko, Y. A., Shantyz, A. K., Luneva, A. V., Shirina, A. A. (2021). Preclinical Studies of Microbial Feed Additives on Laboratory Animals. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 12(11), 12A11H, 1-13. http://doi.org/10.14456/ITJEMAST.2021.218



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Other issues:
Vol.12(12)(2021)
Vol.12(11)(2021)
Vol.12(10)(2021)
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