:: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies
http://TuEngr.com
ISSN 2228-9860
eISSN 1906-9642
CODEN: ITJEA8
FEATURE PEER-REVIEWED ARTICLE
Vol.12(8) (2021) |
Studying the Relationship between Mg and Lymphocytes in Elderly People in Saudi Arabia
Nesrin Tarbiah(Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, SAUDI ARABIA).
Disciplinary: Bioscience & Biochemistry, Medicine & Health Science (Immunology), Nutrition Science.
doi: 10.14456/ITJEMAST.2021.162
Keywords: Immune system; Elderly immunity; B cell; T cell; Elderly nutrition; Mg level; Immunology; Blood test; Immune cells; Mg in elderly people; NK cell.
AbstractMagnesium (Mg) has become a common area of interest for many researchers due to its central role in the immune system. This research studied Mg's impact on the immune system functionality in different age groups in the Saudi population. The influences on the immune system on the ageing process were evident in the production of B and T cells being reduced in the thymus and bone marrow and the lowered mature lymphocytes' function in the secondary lymphoid tissues. Therefore, immuno-senescence was associated with elderly individuals in which their response to immune challenges was not as drastic as with the younger population. Studies have suggested that the impaired immune function and diminished resistance to infection could be nutritional intercession as this may reverse the effects associated with ageing. Two hundred participants of young (25-35 years) and older (55-70 years) Saudi adults of both genders were recruited from Jeddah city, Mg was measured in standards, plasma samples, and blanks (sample diluent) by using inductively coupled plasma-atomic emission spectroscopy. T cell, B cell, and natural killer cell levels were determined by flow cytometry. From the results, our data proved that Mg levels were lower in elderly people compared to the younger group, and had significant effects on the T cell and B cell activity in elderly people.
Paper ID: 12A8O
Cite this article:
Tarbiah, N. (2021). Studying the Relationship between Mg and Lymphocytes in Elderly People in Saudi Arabia. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 12(8), 12A8O, 1-7. http://doi.org/10.14456/ITJEMAST.2021.162
References
- Adolfsson, O., et al. (2001). "Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity." The Journal of Immunology 167(7): 3809-3817.
- Coquette, A., et al. (1986). "Role of vitamin E in the protection of the resident macrophage membrane against oxidative damage." Archives internationales de physiologie et de biochimie 94(5): S29-34.
- Frasca, D., et al. (2011). "Age effects on B cells and humoral immunity in humans." Ageing research reviews 10(3): 330-335.
- Galland, L. (1988). "Magnesium and immune function: an overview." Magnesium 7(5-6): 290-299.
- Goronzy, J. J., et al. (2007). "Aging and T-cell diversity." Experimental gerontology 42(5): 400-406.
- Goronzy, J. J. and C. M. Weyand (2005). "T cell development and receptor diversity during aging." Current opinion in immunology 17(5): 468-475.
- Jones, S. C., et al. (2008). "Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects." The Journal of Immunology 180(7): 4465-4475.
- Larbi, A., et al. (2004). "Age?associated alterations in the recruitment of signal?transduction proteins to lipid rafts in human T lymphocytes." Journal of leukocyte biology 75(2): 373-381.
- Malpuech-Brugere, C., et al. (1998). "Early morphological and immunological alterations in the spleen during magnesium deficiency in the rat." Magnesium research 11(3): 161-169.
- Malpuech-Brugere, C., et al. (1999). "Accelerated thymus involution in magnesium-deficient rats is related to enhanced apoptosis and sensitivity to oxidative stress." British Journal of Nutrition 81(5): 405-411.
- Nagel, J. E., et al. (1988). "Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors." The Journal of clinical investigation 81(4): 1096-1102.
- Pae, M., et al. (2012). "The role of nutrition in enhancing immunity in aging." Aging and disease 3(1): 91.
- Petrault, I., et al. (2002). "Changes in gene expression in rat thymocytes identified by cDNA array support the occurrence of oxidative stress in early magnesium deficiency1." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1586(1): 92-98.
- Roberts-Thomson, I., et al. (1974). "Ageing, immune response, and mortality." The Lancet 304(7877): 368-370.
- Swain, S., et al. (2005). Homeostasis and the age-associated defect of CD4 T cells. Seminars in immunology, Elsevier.
- Tam, M., et al. (2003). "Possible roles of magnesium on the immune system." European journal of clinical nutrition 57(10): 1193-1197.
- Thoman, M. and W. Weigle (1981). "Lymphokines and aging: interleukin-2 production and activity in aged animals." The Journal of Immunology 127(5): 2102-2106.
- Wagner, A., et al. (2018). "Age-related differences in humoral and cellular immune responses after primary immunisation: indications for stratified vaccination schedules." Scientific reports 8(1): 1-12.
- Wayne, S. J., et al. (1990). "Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60." Journal of gerontology 45(2): M45-M48.
Other issues:
Vol.12(9)(2021)
Vol.12(8)(2021)
Vol.12(7)(2021)
Vol.12(6)(2021)
Vol.12(5)(2021)
Vol.12(4)(2021)
Archives
Call-for-Papers
Call-for-Scientific PapersCall-for-Research Papers: ITJEMAST invites you to submit high quality papers for full peer-review and possible publication in areas pertaining engineering, science, management and technology, especially interdisciplinary/cross-disciplinary/multidisciplinary subjects.
To publish your work in the next available issue, your manuscripts together with copyright transfer document signed by all authors can be submitted via email to Editor @ TuEngr.com (no space between). (please see all detail from Instructions for Authors)
Publication and peer-reviewed process:
After the peer-review process (4-10 weeks), articles will be on-line published in the available next issue. However, the International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies cannot guarantee the exact publication time as the process may take longer time, subject to peer-review approval and adjustment of the submitted articles.