:: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies
FEATURE PEER-REVIEWED ARTICLE
Nesrin Tarbiah, Maryam M. Alhemadi, Huda S. Almutairi, Reema S. Alamri (Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, SAUDI ARABIA),
Galila F. Zaher (Department of Hematology, King Abdulaziz University, Jeddah, SAUDI ARABIA),
Alia M. Sabban (Department of Clinical Biochemistry, King Abdulaziz University, Jeddah, SAUDI ARABIA),
Nuha A. Alkhattabi (Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, SAUDI ARABIA).
Disciplinary: Bioscience & Biochemistry, Medicine & Health Science, Biomedical and Biotechnology.
Keywords: Endothelium selectin (E-selectin); Platelet selectin (P-selectin); Lymphocytes (L-selectin); Sickle cell anemia (SCA); Cell adhesion molecules; Vaso-occlusive crises; Intracellular adhesion molecule-1; Vascular cellular adhesion molecule-1 (VCAM-1); Hydroxyurea (HU); ELISA.
Sickle cell anemia (SCA) is a genetic disorder in the blood that is characterized by progressive organ malfunction, painful vaso-occlusive crises, and severe hemolytic anemia. This case-control aimed to compare study of this study is to determine the expression level of adhesion molecules: Vascular Cellular Adhesion Molecule-1 (VCAM-1), Intracellular Adhesion Molecule-1 (ICAM-1), Platelet selectin (P-selectin), and Endothelium selectin (E-selectin) in plasma samples using ELISA technique. This research included 78 males and females, 22 of whom were control individuals, and the rest were divided into 2 groups: steady-state sickle cell patients (SCA), and patients under hydroxyl-urea treatment (SCAHU). The study results indicated that plasma E- and P-selectin expression levels were significantly higher in the SCA group when compared to control groups, but there were no significant differences between the SCAHU and SCA groups for both E and P selectins. There was an increase in the ICAM-1 and VCAM-1 levels in the patient groups when compared to the control group, but they were not statistically significant. Our findings suggest that high expression of P-selectin, E-selectin, VCAM-1, and ICAM-1 predisposes patients to severe manifestations of SCA.
Paper ID: 12A8S
Cite this article:
Tarbiah, N., Alhemadi, M. M., Almutairi, H. S., Alamri, R. S., Zaher, G. F., Sabban, A. M., Alkhattabi, N. A. (2021). Effects of Hydroxyurea on Some Adhesion Molecules in Sickle Cell Anemia Patients. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 12(8), 12A8S, 1-11. http://doi.org/10.14456/ITJEMAST.2021.166