:: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies
http://TuEngr.com
ISSN 2228-9860
eISSN 1906-9642
CODEN: ITJEA8
FEATURE PEER-REVIEWED ARTICLE
Vol.12(9) (2021)Special Issue on the Universiti Teknologi MARA (UiTM) R&D Showcase |
Najihah Mohamad-Nasir (Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor, 40450, MALAYSIA),
Suhaimi Abdul-Talib, Nurul Fariha Lokman (myBioREC, Faculty of Civil Engineering, Universiti Teknologi MARA, Shah Alam, Selangor, 40450, MALAYSIA),
Saiyidah Nafisah Hashim (Faculty of Applied Sciences, Universiti Teknologi MARA, Tapah, Perak, 35400, MALAYSIA),
Chia Chay Tay (Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor, 40450, MALAYSIA and myBioREC, Faculty of Civil Engineering, Universiti Teknologi MARA, Shah Alam, Selangor, 40450, MALAYSIA).
Disciplinary: Environmental and Pollution Sciences & Technology, Chemistry.
doi: 10.14456/ITJEMAST.2021.178
Keywords: Caffeine extraction; Solid Phase Extraction (SPE); Carbamazepine extraction; Liquid-liquid Extraction (LLE); Caffeine Calibration Curve; Pharmaceutical compounds; HPLC; Carbamazepine retention time.
This study focuses on determining the efficient extraction methods between Liquid-liquid Extraction (LLE) and Solid Phase Extraction (SPE) for carbamazepine and caffeine. Optimization on methanol volume was investigated and evaluated through average recovery percentage. Overall, the analytical average recovery percentage of carbamazepine and caffeine was greater than 80% for LLE, while the average recovery percentage for the SPE method was very low (5-35%). Optimum methanol volume for carbamazepine and caffeine extraction was determined at 11 mL. In conclusion, the low-cost LLE method using 11 mL methanol was selected as the efficient method and optimum methanol volume for carbamazepine and caffeine extraction. Statistical analysis showed a significant difference between the methods. The finding sheds light on the reliable and consistent result in further instrumental analysis.
Paper ID: 12A9J
Cite this article:
Mohamad-Nasir, N., Abdul-Talib, S., Lokman, N. F., Hashim, S. N., and Tay, C. C. (2021). Efficient and Low-cost Extraction Methods for Pharmaceutical Compounds of Carbamazepine and Caffeine. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 12(9), 12A9J, 1-9. http://doi.org/10.14456/ITJEMAST.2021.178
References
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Vol.12(9)(2021)
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