International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies


:: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies

ISSN 2228-9860
eISSN 1906-9642



  • Variations of Lung Damage in Autoimmune Liver Diseases

    Adam Isaevich Yanarkaev (North Ossetian State Medical Academy, Vladikavkaz, Republic of North Ossetia-Alania, RUSSIA),
    Madina Zhamarzaevna Dudusheva (Chechen State University named after A.A. Kadyrov, Grozny, Republic of Chechnya, RUSSIA),
    Madina Asrodinovna Alkhuvatova (Saratov State Medical University named after V. I. Razumovsky, Saratov, RUSSIA),
    Alina Aslanovna Avdieva (Rostov State Medical University, Rostov-on-Don, RUSSIA),
    Varvara Igorevna Timofeeva ( Tula State University, Tula, RUSSIA),
    Alina Sarazhdinovna Balkarova (Amicodent Clinic, Saint Petersburg, RUSSIA),
    Alii Khasanovich Semenov (Saratov State Medical University named after V. I. Razumovsky, Saratov, RUSSIA),
    Rukiyat Shamilevna Abdulaeva (Dagestan State Medical University, Makhachkala, Republic of Dagestan, RUSSIA),
    Boris Viktorovich Kalugin (Stavropol State Medical University, Stavropol, RUSSIA),
    Ilez Magomedovich Bulguchev (Moscow State Medical and Dental University named after A. I. Evdokimov, Moscow, RUSSIA),
    Fariza Magomedovna Elmurzayeva (Astrakhan State Medical University, Astrakhan, RUSSIA).

    Discipline: Medicine.

    ➤ FullText

    DOI: 10.14456/ITJEMAST.2022.217

    Keywords: Autoimmune liver diseases, Primary biliary cholangitis, Primary sclerosing cholangitis, Autoimmune hepatitis, Interstitial lung lesions, Computed tomography, Screening studies

    Such pathologies as primary biliary cholangitis, primary sclerosing cholangitis and autoimmune hepatitis are recognized as primary autoimmune liver diseases. According to the results of numerous studies and observations over the past decades, it has been recognized that in addition to lesions of the organs of the hepatobiliary system, there are extrahepatic manifestations of the above diseases, namely, lung lesions in the form of focal and interstitial changes. There is also the possibility of their progression with the development of fibrosis and respiratory failure. Currently, the issue of studying autoimmune liver diseases as systemic with multiple organ lesions is being discussed. There is a possibility of a long-term asymptomatic course of the pulmonary process with the development of irreversible changes in patients with autoimmune liver diseases, therefore, it is considered rational to conduct screening studies that allow timely identification and appropriate therapy of this pathology.

    Paper ID: 13A11G

    Cite this article:

    Yanarkaev, A.I., Dudusheva, M.Zh., Alkhuvatova, M.A., Avdieva, A.A., Timofeeva, V.I., Balkarova, A.S., ... Elmurzayeva, F.M. (2022). Variations of Lung Damage in Autoimmune Liver Diseases. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 13(11), 13A11G, 1-8. http://TUENGR.COM/V13/13A11G.pdf DOI: 10.14456/ITJEMAST.2022.217


  1. Martusewicz-Boros MM, Boros PW, Wiatr E. Respiratory system involvement in chronic liver diseases. Pol Arch Med Wewn. 2013;123(11):635-42. DOI: 10.20452/pamw.1980.
  2. Ayivi R, Ibrahim S, Colleran H, Silva R, Williams L, Galanakis C, Fidan H, Tomovska J and Siddiqui SA. COVID-19: human immune response and the influence of food ingredients and active compounds. Bioactive Compounds in Health and Disease. 2021;4(6):100
  3. Rahim MN, Miquel R, Heneghan MA. Approach to the patient with acute severe autoimmune hepatitis. JHEP Rep. 2020 Jul 21;2(6):100149. DOI: 10.1016/j.jhepr.2020.100149.
  4. Della Corte C, Sartorelli MR, Comparcola D, Alterio A, Giorgio V, Papadatou B, Nobili V. Autoimmune liver diseases. Minerva Pediatr. 2012 Dec;64(6):595-606.
  5. Ziruk, I.V., Egunova, A.V., Kopchekchi, M.E., Frolov, V.V., Babina, K.I.,Povetkin, S.N., Karatunov, V.A. Morphometric of Pig Livers under Different Doses of Minerals in Feed Allowance. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 2020; 11(14), 11A14L, 1-10. DOI: 10.14456/ITJEMAST.2020.277
  6. Wallace ZS, Perugino C, Matza M, Deshpande V, Sharma A, Stone JH. Immunoglobulin G4-related Disease. Clin Chest Med. 2019 Sep;40(3):583-597. DOI: 10.1016/j.ccm.2019.05.005.
  7. Costa C, Sambataro A, Baldi S, Modena V, Todros L, Libertucci D, Coni F, Fusaro E, Revello F, Murgia A, et al. Primary biliary cirrhosis: lung involvement. Liver. 1995 Aug;15(4):196-201. DOI: 10.1111/j.1600-0676.1995.tb00670.x.
  8. Washington, M. Autoimmune liver disease: overlap and outliers. Modern Pathology. 2007; 20, S15-S30
  9. Appanna G, Kallis Y. An update on the management of cholestatic liver diseases. Clin Med (Lond). 2020 Sep;20(5):513-516. DOI: 10.7861/clinmed.2020-0697.
  10. Antunes H, Rocha R, Silva N, Pontes T, Antunes A, Martins S. Immune disease expressed in liver and platelets in an adolescent: a case report. Ital J Pediatr. 2010 Jun 11;36:42. DOI: 10.1186/1824-7288-36-42
  11. Rzhepakovsky I, Anusha Siddiqui S, Avanesyan S, Benlidayi M, Dhingra K, Dolgalev A, Enukashvily N, Fritsch T, Heinz V, Kochergin S, Nagdalian A, Sizonenko M, Timchenko L, Vukovic M, Piskov S, Grimm WD. Anti-arthritic effect of chicken embryo tissue hydrolyzate against adjuvant arthritis in rats (X-ray microtomographic and histopathological analysis). Food Sci Nutr. 2021 Aug 18;9(10):5648-5669. DOI: 10.1002/fsn3.2529
  12. Ferri C, La Civita L, Fazzi P, Solfanelli S, Lombardini F, Begliomini E, Monti M, Longombardo G, Pasero G, Zignego AL. Interstitial lung fibrosis and rheumatic disorders in patients with hepatitis C virus infection. Br J Rheumatol. 1997 Mar;36(3):360-5. DOI: 10.1093/rheumatology/36.3.360.
  13. Rauf A, Abu-Izneid T, Olatunde A, Ahmed Khalil A, Alhumaydhi FA, Tufail T, Shariati MA, Rebezov M, Almarhoon ZM, Mabkhot YN, Alsayari A, Rengasamy KRR. COVID-19 Pandemic: Epidemiology, Etiology, Conventional and Non-Conventional Therapies. International Journal of Environmental Research and Public Health. 2020; 17(21):8155.
  14. Ranjha MMAN, Shafique B, Rehman A, Mehmood A, Ali A, Zahra SM, Roobab U, Singh A, Ibrahim SA and Siddiqui SA. Biocompatible Nanomaterials in Food Science, Technology, and Nutrient Drug Delivery: Recent Developments and Applications. Front. Nutr. 2020; 8:778155. DOI: 10.3389/fnut.2021.778155
  15. Gossard AA, Lindor KD. Autoimmune hepatitis: a review. J Gastroenterol. 2012 May;47(5):498-503. DOI: 10.1007/s00535-012-0586-z.
  16. Fricker ZP, Lichtenstein DR. Primary Sclerosing Cholangitis: A Concise Review of Diagnosis and Management. Dig Dis Sci. 2019 Mar;64(3):632-642. DOI: 10.1007/s10620-019-05484-y
  17. Jonard P, Geubel A, Wallon J, Rahier J, Dive C, Meunier H. Primary sclerosing cholangitis and idiopathic pulmonary fibrosis: a case report. Acta Clin Belg. 1989;44(1):24-30. DOI: 10.1080/17843286.1989.11717982.
  18. Koksal D, Koksal AS, Gurakar A. Pulmonary Manifestations among Patients with Primary Biliary Cirrhosis. J Clin Transl Hepatol. 2016 Sep 28;4(3):258-262. DOI: 10.14218/JCTH.2016.00024.
  19. Lv X, Gao F, Liu Q, Zhang S, Huang Z, Zhu Y, Zong H, Li Q, Li S. Clinical and pathological characteristics of IgG4-related interstitial lung disease. Exp Ther Med. 2018 Feb;15(2):1465-1473. DOI: 10.3892/etm.2017.5554. Epub 2017 Nov 23. Erratum in: Exp Ther Med. 2022 Jan;23(1):95.
  20. Mells GF. Primary biliary cirrhosis: Family, genes, and bugs. Clin Liver Dis (Hoboken). 2014 Apr 28;3(4):69-73. DOI: 10.1002/cld.308.
  21. Ramachandraiah V, Aronow W, Chandy D. Pulmonary sarcoidosis: an update. Postgrad Med. 2017 Jan;129(1):149-158. DOI: 10.1080/00325481.2017.1251818.
  22. Bledzhyants GA, Mishvelov AE, Nuzhnaya KV, Anfinogenova OI, Isakova JA, Melkonyan RS. The Effectiveness of the medical decision-making support system "electronic clinical pharmacologist" in the management of patient's therapeutic profile. Pharmacophore. 2019;10:76-81
  23. Blinov AV, Nagdalian AA, Povetkin SN, Gvozdenko AA, Verevkina MN, Rzhepakovsky IV, Lopteva MS, Maglakelidze DG, Kataeva TS, Blinova AA, Golik AB, Osipchuk GV, Shariati MA. Surface-Oxidized Polymer-Stabilized Silver Nanoparticles as a Covering Component of Suture Materials. Micromachines. 2022; 13(7):1105.
  24. Hite GJ, Mishvelov AE, Melchenko EA, Vlasov AA, Anfinogenova OI, Nuzhnaya CV, et al. Holodoctor planning software real-time surgical intervention. Pharmacophore. 2019;10(3):57-60
  25. Tovlahanova TJH et al. Study of the Effect of the Image Scanning Speed and the Type of Conductive Coating on the Quality of Sem-Micrographs of Oxide Nano Materials for Medical Use. Ann Med Health Sci Res. 2021;11:S3:60-64
  26. Ma WT, Chen DK. Immunological abnormalities in patients with primary biliary cholangitis. Clin Sci (Lond). 2019 Mar 19;133(6):741-760. DOI: 10.1042/CS20181123.
  27. Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M. Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology. 2019 Jan;69(1):394-419. DOI: 10.1002/hep.30145
  28. Vladut C, Ciocirlan M, Bilous D, Sandru V, Stan-Ilie M, Panic N, Becheanu G, Jinga M, Costache RS, Costache DO, Diculescu M. An Overview on Primary Sclerosing Cholangitis. Journal of Clinical Medicine. 2020; 9(3):754.
  29. Mira-Avendano I, Abril A, Burger CD, Dellaripa PF, Fischer A, Gotway MB, Lee AS, Lee JS, Matteson EL, Yi ES, Ryu JH. Interstitial Lung Disease and Other Pulmonary Manifestations in Connective Tissue Diseases. Mayo Clin Proc. 2019 Feb;94(2):309-325. DOI: 10.1016/j.mayocp.2018.09.002
  30. Callea F, Francalanci P, Giovannoni I. Hepatic and Extrahepatic Sources and Manifestations in Endoplasmic Reticulum Storage Diseases. International Journal of Molecular Sciences. 2021; 22(11):5778.

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