International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies


:: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies

ISSN 2228-9860
eISSN 1906-9642



  • Development of an Immunosorbent for the Removal of Atherogenic Lipoproteins from the Body in the Extracorporeal Circulation System

    Saida Ruslanovna Gadzhieva (Clinic (St. Petersburg Medicine), St. Petersburg, RUSSIA),
    Madina Zaurovna Gerbekova (Dental Clinic (Zhemchuzhina), Cherkessk, Republic of Karachay-Cherkessia, RUSSIA),
    Jamila Kazbekovna Chotchaeva (Dental Clinic "Niagara", Cherkessk, Republic of Karachay-Cherkessia, RUSSIA),
    Abdulakh Akhmetovich Nalgiev, Makhmud Bashirovich Yandiev (Moscow State Medical and Dental University named after A. I. Evdokimov, Moscow, RUSSIA),
    Irina Dmitrievna Kormiltseva, Khedi Aslambekovna Akhrieva (Rostov State Medical University, Rostov-on-Don, RUSSIA),
    Mariia Mikhailovna Cherniakova (Moscow State Medical University named after I.M. Sechenov, Moscow, RUSSIA),
    Madina Muslimovna Minatulaeva (North Ossetian State Medical Academy, Vladikavkaz, Republic of North Ossetia-Alania, RUSSIA),
    Zelimkhan Zaindievich Mutsagov (Rostov State Medical University, Rostov-on-Don, RUSSIA).

    Discipline: Medicine, Immunology.

    ➤ FullText

    DOI: 10.14456/ITJEMAST.2022.221

    Keywords:Cardiovascular diseases, Atherosclerotic vascular lesions, Cholesterol, immunosorbent

    Currently, in Russia and the world, cardiovascular diseases (CVD) occupy first place among the causes of mortality in the adult population. The traditional treatment of atherosclerosis, according to modern Russian and foreign recommendations, consists in reducing the level of low-density lipoprotein cholesterol (LDL cholesterol) with statins. The article will describe the developed sorbent with high specificity and is able to effectively remove atherogenic lipoproteins from blood plasma, while it is chemically neutral and relatively inexpensive to manufacture, which allows it to be used in the future in the procedure of therapeutic LDL apheresis for the treatment of severe hypercholesterolemia. The proposed immunosorbent will increase the level of specific capacity relative to antibodies to low-density lipoproteins, and the use of relatively inexpensive components and ready-made sets of antibodies in the process of its synthesis will ensure the economic attractiveness of the final product.

    Paper ID: 13A11K

    Cite this article:

    Gadzhieva, S.R., Gerbekova, M.Z., Chotchaeva, J.K., Nalgiev, A.A., Yandiev, M.B., Kormiltseva, I.D., Akhrieva, Kh.A., Cherniakova, M.M., Minatulaeva, M.M., Mutsagov, Z.Z. (2022). Development of an Immunosorbent for the Removal of Atherogenic Lipoproteins from the Body in the Extracorporeal Circulation System. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 13(11), 13A11K, 1-10. http://TUENGR.COM/V13/13A11K.pdf DOI: 10.14456/ITJEMAST.2022.221


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