International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies

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:: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies

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ISSN 2228-9860
eISSN 1906-9642
CODEN: ITJEA8


FEATURE PEER-REVIEWED ARTICLE

Vol.13(12)(2022)

  • Features of B. anthracis Vaccine Strains for the Production of Anthrax Vaccines

    Lusine Tsaturyan (Department of Bacteriology, The Russian State Center For Animal Feed And Drug Standardization And Quality, RUSSIA),
    Oleg Sklyarov (Department of Scientific Planning and Research, The Russian State Center For Animal Feed And Drug Standardization And Quality, RUSSIA),

    Discipline: Veterinary bacteriology

    ➤ FullText

    doi: 10.14456/ITJEMAST.2022.242

    Keywords:Anthrax; Vaccine; Immunogenicity; Safety; Strain; Virulence; Spores; Protective properties

    Abstract
    This article presents the results of a comparative study of the cultural, morphological, biological and protective properties of current or proposed vaccine strains against anthrax B. anthracis 34F2, 55-VNIIVViM, STI-1, 1190-R - Stamatin, Pasteur, Shuya-15, 916- 1, No. 94, Mato, Ihtiman. All strains are attenuated. The mass fraction of spores of strains after cultivation on beef-peptone agar (MPA) was 90-98%. ImD50 of vaccine strains for guinea pigs was: 55-VNIIVViM - 0.34; 34F2 and STI -1 - 0.58; Ihtiman - 0.76, Shuya-15, 916-1, No. 94, Mato- 1.71, 1190-R - Stamatin - 3.14; Pasteur - 0.05 million spores. B. anthracis strains 55-VNIIVViM, 34F2, STI-1 at a dose of 10 ImD50 and B. anthracis Pasteur strain at a dose of 5 ImD50 provided protection against infection by a culture of the control weakly virulent B. anthracis M-71 capsular strain at a dose of 1.0 million live spores of 100% immunized guinea pigs.

    Paper ID: 13A12K

    Cite this article:

    Tsaturyan, L. and Sklyarov, O. (2022). Features of B. anthracis Vaccine Strains for the Production of Anthrax Vaccines. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 13(12), 13A12K, 1-10. http://TUENGR.COM/V13/13A12K.pdf DOI: 10.14456/ITJEMAST.2022.242

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Other issues:
Vol.13(11)(2022)
Vol.13(10)(2022)
Vol.13(9)(2022)
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