Bromelain as a Potential Material in Future Chemotherapy: A Review

References

1. Ahmad, F.Y., & Carmen, A. (2017). Revisiting the hallmarks of cancer. Anales Venezolanos de Nutricion, 7(1), 62.
2. Ahn, C. S., & Metallo, C. M. (2015). Mitochondria as biosynthetic factories for cancer proliferation. Cancer and Metabolism, 3(1), 1-10.
3. Amini Chermahini, F., Raeisi, E., Aazami, M. H., Mirzaei, A., Heidarian, E., & Lemoigne, Y. (2020). Does Bromelain-Cisplatin Combination Afford In-Vitro Synergistic Anticancer Effects on Human Prostatic Carcinoma Cell Line, PC3? Galen Medical Journal, 9, 1749.
4. Beez, R., Lopes, M. T. P., Salas, C. E., & Hernandez, M. (2007). In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain. Planta Medica, 73(13), 1377-1383.
5. Bhatnagar, P., Patnaik, S., Srivastava, A. K., Mudiam, M. K. R., Shukla, Y., Panda, A. K., Pant, A. B., Kumar, P., & Gupta, K. C. (2014). Anti-Cancer activity of bromelain nanoparticles by oral administration. Journal of Biomedical Nanotechnology, 10(12), 3558-3575.
6. Bhattacharyya, B. K. (2008). Bromelain: An overview. Indian Journal of Natural Products and Resources, 7(4), 359-363.
7. Bhui, K., Prasad, S., George, J., & Shukla, Y. (2009). Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway. Cancer Letters, 282(2), 167-176.
8. Bhui, K., Tyagi, S., Prakash, B., & Shukla, Y. (2010). Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells. BioFactors, 36(6), 474-482.
9. Bhui, K., Tyagi, S., Srivastava, A. K., Singh, M., Roy, P., & Singh, R. (2012). Bromelain Inhibits Nuclear Factor Kappa-B Translocation , Driving Human Epidermoid Carcinoma A431 and Melanoma A375 Cells Through G 2 / M Arrest to Apoptosis. 243(January 2011), 231-243.
10. Chaffer, C. L., & Weinberg, R. A. (2011). A perspective on cancer cell metastasis. Science, 331(6024), 1559-1564.
11. Chang, T. C., Wei, P. L., Makondi, P. T., Chen, W. T., Huang, C. Y., & Chang, Y. J. (2019). Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy. PLoS ONE, 14(1), 1-18.
12. Chobotova, K., Vernallis, A. B., & Majid, F. A. A. (2010). Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives. Cancer Letters, 290(2), 148-156.
13. Coussens, L. M., & Werb, Z. (2002). Inflammation and cancer. Nature, 420(December), 860-867.
14. DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008). The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation. Cell Metabolism, 7(1), 11-20.
15. Dhaval, A., Yadav, N., & Purwar, S. (2016). Potential applications of food derived bioactive peptides in management of health. International Journal of Peptide Research and Therapeutics, 22(3), 377-398.
16. Doughlas, H., & Weinberg, R. A. (2000). The Hallmarks of Cancer. Cell, 100(1), 57-70.
17. Egeblad, M., & Werb, Z. (2002). New functions for the matrix metalloproteinases in cancer progression. Nature Reviews Cancer, 2(3), 161-174.
18. Elledge, S. J. (1996). Cell cycle checkpoints: Preventing an identity crisis. Science, 274(5293), 1664-1672.
19. Engwerda, C. R., Andrew, D., Murphy, M., & Mynott, T. L. (2001). Bromelain activates murine macrophages and natural killer cells in vitro. Cellular Immunology, 210(1), 5-10.
20. Evan, G. I., & Vousden, K. H. (2001). Proliferation, cell cycle and apoptosis in cancer. Nature, 411(6835), 342-348.
21. Fitzhugh, D. J., Shan, S., Dewhirst, M. W., & Hale, L. P. (2008). Bromelain treatment decreases neutrophil migration to sites of inflammation. Clinical Immunology, 128(1), 66-74.
22. Folkman, J. (1985). Tumor Angiogenesis. Advances in Cancer Research, 43(C), 175-203.
23. Folkman, J. (1995). Clinical Application of Research on Angiogenesis. New England Journal of Medicinegland, 333(26), 1757-1763.
24. Fouz, N., Amid, A., & Hashim, Y. Z. H. Y. (2013). Cytokinetic study of MCF-7 cells treated with commercial and recombinant bromelain. Asian Pacific Journal of Cancer Prevention, 14(11), 6709-6714.
25. Gariglio, P. (2012). Oncogenes and tumor suppressor genes. Molecular Oncology Principles and Recent Advances, 64-82.
26. Grivennikov, S. I., Greten, F. R., & Karin, M. (2010). Immunity, Inflammation, and Cancer. Cell, 140(6), 883-899.
27. Gupta, G. P., & Massague, J. (2006). Cancer Metastasis: Building a Framework. Cell, 127(4), 679-695.
28. Hale, L. P., Greer, P. K., Trinh, C. T., & James, C. L. (2005). Proteinase activity and stability of natural bromelain preparations. International Immunopharmacology, 5(4), 783-793.
29. Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: The next generation. Cell, 144(5), 646-674.
30. Haupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003). Apoptosis - The p53 network. Journal of Cell Science, 116(20), 4077-4085.
31. Kalra, N., Bhui, K., Roy, P., Srivastava, S., George, J., Prasad, S., & Shukla, Y. (2008). Regulation of p53, nuclear factor kB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin. Toxicology and Applied Pharmacology, 226(1), 30-37.
32. Kastan, M. B., & Bartek, J. (2004). Cell-cycle checkpoints and cancer. Nature, 432(7015), 316-323.
33. Kerbel, R. S. (2008). Tumor Angiogenesis. New England Journal of Medicine, 358(9), 2039-2049.
34. Kerr, J. F. R., Winterford, C. M., & Harmon, B. V. (1994). Apoptosis. Its significance in cancer and cancer Therapy. Cancer, 73(8), 2013-2026.
35. Levine, A. J., & Puzio-Kuter, A. M. (2010). The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science, 330(6009), 1340-1344.
36. Lim, S., & Kaldis, P. (2013). Cdks, cyclins and CKIs: Roles beyond cell cycle regulation. Development (Cambridge) , 140(15), 3079-3093.
37. Mamo, J., & Assefa, F. (2019). Antibacterial and Anticancer Property of Bromelain: A Plant Protease Enzyme from Pineapples (Ananas comosus). Curr Trends Biomedical Eng & Biosci., 19(2), 60-68.
38. Manosroi, W., Chankhampan, C., Manosroi, J., & Manosroi, A. (2017). In vitro anti-cancer activity comparison of the freeze-dried and spray-dried bromelain from pineapple stems. Chiang Mai Journal of Science, 44(4), 1407-1418.
39. Martin, S. J. (2014). Caspases: Executioners of Apoptosis. Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms, 16, 145-152.
40. Maurer, H. R. (2001). Bromelain: Biochemistry, pharmacology and medical use. Cellular and Molecular Life Sciences, 58(9), 1234-1245.
41. Mohamad, N. E., Abu, N., Yeap, S. K., & Alitheen, N. B. (2019). Bromelain Enhances the Anti-tumor Effects of Cisplatin on 4T1 Breast Tumor Model In Vivo. Integrative Cancer Therapies, 18, 0-6.
42. Muller, A., Barat, S., Chen, X., Bui, K. C., Bozko, P., Malek, N. P., & Plentz, R. R. (2016). Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines. International Journal of Oncology, 48(5), 2025-2034.
43. Muller, S., Marz, R., Schmolz, M., Drewelow, B., Eschmann, K., & Meiser, P. (2013). Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high- dose bromelain after oral.pdf. 204(February 2012), 199-204.
44. Munzig, E., Eckert, K., Harrach, T., Graf, H., & Maurer, H. R. (1994). Bromelain protease F9 reduces the CD44 mediated adhesion of human peripheral blood lymphocytes to human umbilical vein endothelial cells. FEBS Letters, 351(2), 215-218.
45. Mynott, T. L., Ladhams, A., Scarmato, P., & Engwerda, C. R. (1999). Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells. Journal of Immunology (Baltimore, Md.: 1950) , 163(5), 2568-2575.
46. Oliveira, C. P., Prado, W. A., Lavayen, V., Buttenbender, S. L., Beckenkamp, A., Martins, B. S., Ludtke, D. S., Campo, L. F., Rodembusch, F. S., Buffon, A., Pessoa, A., Guterres, S. S., & Pohlmann, A. R. (2017). Bromelain-Functionalized Multiple-Wall Lipid-Core Nanocapsules: Formulation, Chemical Structure and Antiproliferative Effect Against Human Breast Cancer Cells (MCF-7). Pharmaceutical Research, 34(2), 438-452.
47. Paroulek, A. F., Jaffe, M., & Rathinavelu, A. (2010). The effects of the herbal enzyme bromelain against breast cancer cell line GI-101A.
48. Pavan, R., Jain, S., Shraddha, & Kumar, A. (2012). Properties and Therapeutic Application of Bromelain: A Review. Biotechnology Research International, 2012, 1-6.
49. Pillai, K., Ehteda, A., Akhter, J., Chua, T. C., & Morris, D. L. (2014). Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells. Anti-Cancer Drugs, 25(2), 150-160.
50. Raeisi, F., Raeisi, E., Heidarian, E., Shahbazi-Gahroui, D., & Lemoigne, Y. (2019). Bromelain inhibitory effect on colony formation: An in vitro Study on human AGS, PC3, and MCF7 cancer cells. Journal of Medical Signals and Sensors, 9(4), 267-273.
51. Sagar, S. M., Yance, D., & Wong, R. K. (2006). Natural health products that inhibit angiogenesis: A potential source for investigational new agents to treat cancer - Part 2. Current Oncology, 13(3), 14-26.
52. Sasaki, T., Hiroki, K., & Yamashita, Y. (2013). The role of epidermal growth factor receptor in cancer metastasis and microenvironment. BioMed Research International, 2013.
53. Senger, D. R., & Davis, G. E. (2011). Angiogenesis. 1-20.
54. Tochi, B. N., Wang, Z., Xu, S. Y., & Zhang, W. (2008). Therapeutic Application of Pineapple Protease ( Bromelain ): A Review. 7(4), 513-520.
55. Torgovnick, A., & Schumacher, B. (2015). DNA repair mechanisms in cancer development and therapy. Frontiers in Genetics, 6(APR), 1-15.
56. Vermeulen, K., Van Bockstaele, D. R., & Berneman, Z. N. (2005). Apoptosis: Mechanisms and relevance in cancer. Annals of Hematology, 84(10), 627-639.
57. Zhang, L., Yu, J., Park, B. H., Kinzler, K. W., & Vogelstein, B. (2000). Role of BAX in the Apoptotic Response to Anticancer Agents. Science, 290, 989-992.