International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies


:: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies

ISSN 2228-9860
eISSN 1906-9642



  • Fundamentals of Pathophysiological Mechanisms of Brugada Syndrome and Analysis of Modern Strategies for Its Therapy

    Turpal-Ali Alievich Aliev (Saratov State Medical University named after V.I.Razumovsky, Saratov, RUSSIA),
    Diana Muradovna Yandieva (Ingush State University, Magas city, Republic of Ingushetia, RUSSIA),
    Elina Stanislavovna Petrova (North Ossetian State Medical Academy, Vladikavkaz, Republic of North Ossetia, RUSSIA),
    Daniil Vitalievich Solomka, Ksenia Evgenievna Tkachenko, Ellina Sohrabovna Mehdieva, Denis Sergeevich Tarasenko, Alina Yurievna Maslova (Stavropol State Medical University, Stavropol, RUSSIA),
    Alina Yurievna Maslova (Socmedica, Skolkovo, Moscow, RUSSIA).

    Disciplinary: Medicine.

    ➤ FullText

    DOI: 10.14456/ITJEMAST.2022.151

    Keywords: Brugada syndrome; Sudden cardiac death; Pathology; T-wave; ECG; Electrocardio-stimulator; Q-T; P-R; SCN5A; Fibrillation.

    Sudden cardiac death is one of the leading causes of death with a high level of urbanization. Brugada syndrome is a genetically determined cardiac arrhythmia characterized by syncopal states, ST-segment rises (from point J) above the isoelectric line in the right precordial leads (V1V3), which can disappear transiently, also inverted T wave, complete or incomplete blockage of the legs of the Gis beam, periodic elongation can be registered in these leads PR interval with a high risk of life-threatening ventricular tachyarrhythmias (episodes of polymorphic ventricular tachycardia and ventricular fibrillation), usually developing in a dream or in a calm state. Often, patients also have supraventricular arrhythmias, more often atrial fibrillation. Over 15 years of studying pathology, data on acquired Brugada syndrome have accumulated. Changes in the ECG by the type of Brugada-like, without clinical confirmation of the syndrome, can be observed in patients with chest excavation, with hemopericardium. There are currently no convincing agreed data on the effectiveness of any medications in the long-term prevention of seizures, or they are contradictory. For patients with a high risk of sudden cardiac death, the method of therapy that increases life expectancy is the implantation of an electrocardio stimulator.

    Paper ID: 13A8D

    Cite this article:

    Aliev, T.A., Yandieva, D.M., Petrova E.S., Solomka, D.V., Tkachenko, K.E., Mehdieva, E.S., ... Maslova, A.Y. (2022). Fundamentals of Pathophysiological Mechanisms of Brugada Syndrome and Analysis of Modern Strategies for Its Therapy. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 13(8), 13A8D, 1-9. http://TUENGR.COM/V13/13A8D.pdf DOI: 10.14456/ITJEMAST.2022.151


  1. Maslova AY, Bazaeva KL, Abdullaeva ZA, Khazamova SO, Zeusheva KA, Grechkina TA, Semkina EN, Abramov MA, Mishvelov AE, Povetkin SN. Astrocytes and their Phenomenal Possibilities in the Treatment of Various Neurodegenerative Disorders: An Overview. Journal of Pharmaceutical Research International, 2021; 33(33A), 60-68. DOI: 10.9734/jpri/2021/v33i33A31772
  2. Gourraud JB, Barc J, Thollet A, Le Marec H, Probst V. Brugada syndrome: Diagnosis, risk stratification and management. Arch Cardiovasc Dis. 2017 Mar;110(3):188-195. DOI: 10.1016/j.acvd.2016.09.009
  3. Tovlahanova TJH, et al. Study of the Effect of the Image Scanning Speed and the Type of Conductive Coating on the Quality of Sem-Micrographs of Oxide Nano Materials for Medical Use. Ann Med Health Sci Res. 2021;11,S3:60-64
  4. Kuriachan VP, Sumner GL, Mitchell LB. Sudden cardiac death. Curr Probl Cardiol. 2015 Apr;40(4):133-200. DOI: 10.1016/j.cpcardiol.2015.01.002.
  5. Areshidze DA, Mischenko DV, Makartseva LA, Rzhepakovsky IV, Nagdalian AA. Some functional measures of the organism of rats at modeling of ischemic heart disease in two different ways. Entomology and Applied Science, 2018;5(4):2349-2864
  6. Francis J, Antzelevitch C. Brugada syndrome. Int J Cardiol. 2005 May 25;101(2):173-8. DOI: 10.1016/j.ijcard.2004.03.068
  7. Probst V, Evain S, Gournay V, Marie A, Schott JJ, Boisseau P, LE Marec H. Monomorphic ventricular tachycardia due to Brugada syndrome successfully treated by hydroquinidine therapy in a 3-year-old child. J Cardiovasc Electrophysiol. 2006 Jan;17(1):97-100. DOI: 10.1111/j.1540-8167.2005.00329.x.
  8. Espinosa A, Ripolles-Melchor J, Brugada R, Campuzano O, Sarquella-Brugada G, Abad-Motos A, Zaballos-Garcia M, Abad-Torrent A, Prieto-Gundin A, Brugada J. Brugada Syndrome: anesthetic considerations and management algorithm. Minerva Anestesiol. 2019 Feb;85(2):173-188. DOI: 10.23736/S0375-9393.18.13170-1
  9. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol. 1992 Nov 15;20(6):1391-6. DOI: 10.1016/0735-1097(92)90253-j.
  10. Verrier RL, Nieminen T. T-wave alternans as a therapeutic marker for antiarrhythmic agents. J Cardiovasc Pharmacol. 2010 Jun;55(6):544-54. DOI: 10.1097/FJC.0b013e3181d6b781.
  11. Rzhepakovsky I, Anusha Siddiqui S, Avanesyan S, Benlidayi M, Dhingra K, Dolgalev A, Enukashvily N, Fritsch T, Heinz V, Kochergin S, Nagdalian A, Sizonenko M, Timchenko L, Vukovic M, Piskov S, Grimm WD. Anti-arthritic effect of chicken embryo tissue hydrolyzate against adjuvant arthritis in rats (X-ray microtomographic and histopathological analysis). Food Sci Nutr. 2021 Aug 18;9(10):5648-5669. DOI: 10.1002/fsn3.2529
  12. Siddiqui SA, Ali Redha A, Snoeck ER, Singh S, Simal-Gandara J, Ibrahim SA, Jafari SM. Anti-Depressant Properties of Crocin Molecules in Saffron. Molecules. 2022; 27(7):2076. DOI: 10.3390/molecules27072076
  13. Gutnova, T. S., Kompantsev, D. V., Gvozdenko, A. A., Kramarenko, V. N., & Blinov, A. V. VITAMIN D NANOCAPSULATION. IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA, 2021;64(5):98-105. DOI: 10.6060/ivkkt.20216405.6399
  14. Di Diego JM, Patocskai B, Barajas-Martinez H, Borb?th V, Ackerman MJ, Burashnikov A, Clatot J, Li GR, Robinson VM, Hu D, Antzelevitch C. Acacetin suppresses the electrocardiographic and arrhythmic manifestations of the J wave syndromes. PLoS One. 2020;15(11):e0242747. DOI: 10.1371/journal.pone.0242747
  15. Morita H, Zipes DP, Lopshire J, Morita ST, Wu J. T wave alternans in an in vitro canine tissue model of Brugada syndrome. Am J Physiol Heart Circ Physiol. 2006;291(1):H421-8. DOI: 10.1152/ajpheart.01259.2005.
  16. Rzhepakovsky IV, Areshidze DA, Avanesyan SS, Grimm WD, Filatova NV, Kalinin AV, Kochergin SG, Kozlova MA, Kurchenko VP, Sizonenko MN, Terentiev AA, Timchenko LD, Trigub MM, Nagdalian AA, Piskov SI. Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq. Molecules. 2022; 27(3):762. DOI: 10.3390/molecules27030762
  17. Babaliaros VC, Hurst JW. Tricyclic antidepressants and the Brugada syndrome: an example of Brugada waves appearing after the administration of desipramine. Clin Cardiol. 2002;25(8):395-8. DOI: 10.1002/clc.4950250809
  18. Maslova, A. Y., Tskaeva, A. A., Ashurova, Z. A., Abazova, A., Ismailov, M. M., Ismailova, M. M., Baklanov, I. S., Mishvelov, A. E., Povetkin, S. N. and Baklanova, O. A. Study of the effect of Baricitinib on the Course of COVID-19, Journal of Pharmaceutical Research International, 2021; 33(35A):204-213. DOI: 10.9734/jpri/2021/v33i35A31890
  19. Mehdizadeh, Mohammad, Mushtaq, Waseem, Siddiqui, Shahida, Al-Taey, Duraid, Tampubolon, Koko. Assessment of Phytotoxins Using Different Technologies. Current Applied Science and Technology. 2020; 22. 1-19. 10.55003/cast.2022.04.22.010 Muench J, Hamer AM. Adverse effects of antipsychotic medications. Am Fam Physician. 2010;81(5):617-22
  20. Furuhashi M, Uno K, Tsuchihashi K, Nagahara D, Hyakukoku M, Ohtomo T, Satoh S, Nishimiya T, Shimamoto K. Prevalence of asymptomatic ST segment elevation in right precordial leads with right bundle branch block (Brugada-type ST shift) among the general Japanese population. Heart. 2001;86(2):161-6. DOI: 10.1136/heart.86.2.161
  21. Antzelevitch C, Yan GX. J-wave syndromes: Brugada and early repolarization syndromes. Heart Rhythm. 2015 Aug;12(8):1852-66. DOI: 10.1016/j.hrthm.2015.04.014
  22. Tada H, Sticherling C, Oral H, Morady F. Brugada syndrome mimicked by tricyclic antidepressant overdose. J Cardiovasc Electrophysiol. 2001;12(2):275. DOI: 10.1046/j.1540-8167.2001.00275.x
  23. Chinushi M, Aizawa Y, Ogawa Y, Shiba M, Takahashi K. Discrepant drug action of disopyramide on ECG abnormalities and induction of ventricular arrhythmias in a patient with Brugada syndrome. J Electrocardiol. 1997;30(2):133-6. DOI: 10.1016/s0022-0736(97)80021-0
  24. Brugada J, Brugada R, Brugada P. Right bundle-branch block and ST-segment elevation in leads V1 through V3: a marker for sudden death in patients without demonstrable structural heart disease. Circulation. 1998;97(5):457-60. DOI: 10.1161/01.cir.97.5.457
  25. Mizusawa Y, Sakurada H, Nishizaki M, Hiraoka M. Effects of low-dose quinidine on ventricular tachyarrhythmias in patients with Brugada syndrome: low-dose quinidine therapy as an adjunctive treatment. J Cardiovasc Pharmacol. 2006;47(3):359-64. DOI: 10.1097/01.fjc.0000206437.27854.65
  26. Cheng WH, Chung FP, Lin YJ, Lo LW, Chang SL, Hu YF, Tuan TC, Chao TF, Liao JN, Lin CY, Chang TY, Kuo L, Wu CI, Liu CM, Liu SH, Chen SA. Arrhythmogenic right ventricular cardiomyopathy: diverse substrate characteristics and ablation outcome. Rev Cardiovasc Med. 2021;22(4):1295-1309. DOI: 10.31083/j.rcm2204136
  27. Alings M, Wilde A. "Brugada" syndrome: clinical data and suggested pathophysiological mechanism. Circulation. 1999;99(5):666-73. DOI: 10.1161/01.cir.99.5.666
  28. Munjal, A. & Khandia, R. & Paladhi, S.& Katare, M. & Parihar, A. & Pathe, C. & Rajukumar, K. & Emran, T., Alqahtani, T., Alqahtani, A., Alamri, A. & Chidambaram, K. & Dhama, K. Evaluating the Effects of Hypotensive Drug Valsartan on Angiogenesis and Associated Breast Ductal Carcinoma Cell Metastasis. International Journal of Pharmacology. 2022;18:817-825. 10.3923/ijp.2022.817.825
  29. Khandia R, Puranik N, Lodhi N, Gautam B, Alqahtani T, Alqahtani AM, Alamri AH, Chidambaram K. Comparing heart risk scores to identify the most important risk factors for cardiovascular diseases. Eur Rev Med Pharmacol Sci. 2021;25(24):7947-7963. DOI: 10.26355/eurrev_202112_27645
  30. Di Diego JM, Patocskai B, Barajas-Martinez H, Borbath V, Ackerman MJ, Burashnikov A, Clatot J, Li GR, Robinson VM, Hu D, Antzelevitch C. Acacetin suppresses the electrocardiographic and arrhythmic manifestations of the J wave syndromes. PLoS One. 2020;15(11):e0242747. DOI: 10.1371/journal.pone.0242747

Other issues:


Call-for-Scientific Papers
Call-for-Research Papers:
ITJEMAST invites you to submit high quality papers for full peer-review and possible publication in areas pertaining engineering, science, management and technology, especially interdisciplinary/cross-disciplinary/multidisciplinary subjects.

To publish your work in the next available issue, your manuscripts together with copyright transfer document signed by all authors can be submitted via email to Editor @ (no space between). (please see all detail from Instructions for Authors)

Publication and peer-reviewed process:
After the peer-review process (4-10 weeks), articles will be on-line published in the available next issue. However, the International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies cannot guarantee the exact publication time as the process may take longer time, subject to peer-review approval and adjustment of the submitted articles.