International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies


:: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies

ISSN 2228-9860
eISSN 1906-9642



  • Molecular Aspects of Creating Therapeutic and Vaccine Strategies against Ebola Virus Disease

    Adam Saidalvievich Babatkhanov (Saratov State Medical University, Saratov, RUSSIA),
    Zuleykha Abdulkerim kizi Ashurova (Dagestan State Medical University, Makhachkala, Republic of Dagestan, RUSSIA).
    Khalid Shamilevich Nasurov (Saratov State Medical University, Saratov, RUSSIA),
    Zalina Stalinbekovna Gurieva, Lora Khasanbekovna Dzotsieva (North Ossetian State Medical Academy, Republic of North Ossetia-Alania, Vladikavkaz, RUSSIA),
    Artem Evgenievich Mishvelov(Stavropol State Medical University, Stavropol, RUSSIA),
    (Socmedica, Skolkovo, Moscow, RUSSIA),
    Zhanna Grigorievna Plieva, Galimat Abdurashidovna Gipaeva, Aslanbek Muratbekovich Dzgoev (North Ossetian State Medical Academy, Republic of North Ossetia-Alania, Vladikavkaz, RUSSIA).

    Disciplinary: Medicine.

    ➤ FullText

    doi: 10.14456/ITJEMAST.2022.164

    Keywords: Ebola virus; Immunity; Epidemic; Pandemic; Disease

    The disease caused by the Ebola virus is an exceptional danger to public health due to the high mortality rate combined with the actual absence of antiviral therapy and an effective vaccination algorithm, as well as the main pathogen of the biological threat of the highest category. This state of affairs explains the inclusion of The disease caused by the Ebola virus in the list of diseases covered by the International Health Regulations of 2005. Both the epidemic of 2014-2015 and the real pandemic with VID-19 showed the exceptional inadequacy and unpreparedness of the world health care for such a large-scale disaster. The relevance of this topic lies in the consideration of this problem through the analysis of the experience of the Ebola epidemic and the construction of correlations with today's pandemic.

    Paper ID: 13A8Q

    Cite this article:

    Babatkhanov, A.S., Ashurova, Z.A., Nasurov, Kh.Sh., Gurieva, Z.S., Dzotsieva, L.Kh., Mishvelov, A. E., ... Dzgoev, A.M. (2022). Molecular Aspects of Creating Therapeutic and Vaccine Strategies against Ebola Virus Disease. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 13(8), 13A8Q, 1-7. http://TUENGR.COM/V13/13A8Q.pdf DOI: 10.14456/ITJEMAST.2022.164


  1. Zimmerman T, Siddiqui SA, Bischoff W, Ibrahim SA. Tackling airborne virus threats in the food industry: A proactive approach. International Journal of Environmental Research and Public Health. 2021;18(8):4335.
  2. Rauf A, Abu-Izneid T, Olatunde A, Ahmed Khalil A, Alhumaydhi FA, Tufail T, Shariati MA, Rebezov M, Almarhoon ZM, Mabkhot YN, Alsayari A. COVID-19 pandemic: epidemiology, etiology, conventional and non-conventional therapies. International Journal of Environmental Research and Public Health. 2020;17(21):8155.
  3. Feldmann H, Jones SM, Daddario-DiCaprio KM, Geisbert JB, Str?her U, Grolla A, Bray M, Fritz EA, Fernando L, Feldmann F, Hensley LE. Effective post-exposure treatment of Ebola infection. PLoS pathogens. 2007;3(1):e2.
  4. Falzarano D, Geisbert TW, Feldmann H. Progress in filovirus vaccine development: evaluating the potential for clinical use. Expert review of vaccines. 2011;10(1):63-77.
  5. Cross RW, Bornholdt ZA, Prasad AN, Geisbert JB, Borisevich V, Agans KN, Deer DJ, Melody K, Fenton KA, Feldmann H, Sprecher A. Prior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment. Nature communications. 2020;11(1):1-8.
  6. Matassov D, Marzi A, Latham T, Xu R, Ota-Setlik A, Feldmann F, Geisbert JB, Mire CE, Hamm S, Nowak B, Egan MA. Vaccination with a highly attenuated recombinant vesicular stomatitis virus vector protects against challenge with a lethal dose of Ebola virus. The Journal of infectious diseases. 2015;212(suppl_2):S443-51.
  7. Kortepeter MG, Dierberg K, Shenoy ES, Cieslak TJ. Marburg virus disease: A summary for clinicians. International Journal of Infectious Diseases. 2020 ;99:233-42.
  8. Khandia R, Ali Khan A, Alexiou A, Povetkin SN, Nikolaevna VM. Codon usage analysis of pro-apoptotic bim gene isoforms. Journal of Alzheimer's Disease. 2022(Preprint):1-6. Bausch DG, Geisbert TW. Development of vaccines for Marburg hemorrhagic fever. Expert Rev Vaccines. 2007;6(1):57-74. doi: 10.1586/14760584.6.1.57
  9. Geisbert TW, Hensley LE, Gibb TR, Steele KE, Jaax NK, Jahrling PB. Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses. Laboratory investigation. 2000;80(2):171-86.
  10. Johnston SC, Wilhelmsen CL, Shamblin J, Kimmel A, Zelko J, Wollen S, Goff AJ. Delayed Disease in Cynomolgus Macaques Exposed to Ebola Virus by an Intranasal Route. Frontiers in Immunology. 2021:2940.
  11. Geisbert TW, Hensley LE, Larsen T, Young HA, Reed DS, Geisbert JB, Scott DP, Kagan E, Jahrling PB, Davis KJ. Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection. The American journal of pathology. 2003;163(6):2347-70.
  12. Guo JT, Hayashi J, Seeger C. West Nile virus inhibits the signal transduction pathway of alpha interferon. Journal of virology. 2005;79(3):1343-50.
  13. Hensley LE, Jones SM, Feldmann H, Jahrling PB, Geisbert TW. Ebola and Marburg viruses: pathogenesis and development of countermeasures. Current molecular medicine. 2005;5(8):761-72.
  14. Hofmann-Winkler H, Kaup F, P?hlmann S. Host cell factors in filovirus entry: novel players, new insights. Viruses. 2012;4(12):3336-62.
  15. Ranjha MM, Shafique B, Rehman A, Mehmood A, Ali A, Zahra SM, Nasreen S, Singh A, Ibrahim SA, Siddiqui SA. Biocompatible Nanomaterials in Food Science, Technology and Nutrient Drug Delivery: Recent Developments and Applications. Frontiers in Nutrition. 2021:1141.
  16. SOK K. Astrocytes and their phenomenal possibilities in the treatment of various neurodegenerative disorders: An overview.
  17. Siddiqui SA, Bahmid NA, Taha A, Khalifa I, Khan S, Rostamabadi H, Jafari SM. Recent advances in food applications of phenolic-loaded micro/nanodelivery systems. Critical Reviews in Food Science and Nutrition. 2022:1-21.
  18. Hunt CL, Lennemann NJ, Maury W. Filovirus entry: a novelty in the viral fusion world. Viruses. 2012;4(2):258-75.
  19. Jones SM, Feldmann H, Str?her U, Geisbert JB, Fernando L, Grolla A, Klenk HD, Sullivan NJ, Volchkov VE, Fritz EA, Daddario KM. Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses. Nature medicine. 2005;11(7):786-90.
  20. Siddiqui SA, Ali Redha A, Snoeck ER, Singh S, Simal-Gandara J, Ibrahim SA, Jafari SM. Anti-Depressant Properties of Crocin Molecules in Saffron. Molecules. 2022;27(7):2076.
  21. Ayivi R, Ibrahim SA, Colleran H, Silva R, Williams L, Galanakis C, Fidan H, Tomovska J, Siddiqui SA. COVID-19: human immune response and the influence of food ingredients and active compounds. Bioactive Compounds in Health and Disease. 2021;4(6):100-48.
  22. Lee JE, Fusco ML, Hessell AJ, Oswald WB, Burton DR, Saphire EO. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature. 2008;454(7201):177-82.
  23. Rzhepakovsky IV, Areshidze DA, Avanesyan SS, Grimm WD, Filatova NV, Kalinin AV, Kochergin SG, Kozlova MA, Kurchenko VP, Sizonenko MN, Terentiev AA. Phytochemical characterization, antioxidant activity, and cytotoxicity of methanolic leaf extract of Chlorophytum Comosum (green type)(Thunb.) Jacq. Molecules. 2022;27(3):762.
  24. Mu?hlberger E, Weik M, Volchkov VE, Klenk HD, Becker S. Comparison of the transcription and replication strategies of Marburg virus and Ebola virus by using artificial replication systems. Journal of virology. 1999;73(3):2333-42.
  25. Gutnova TS, Kompantsev DV, Gvozdenko AA, Kramarenko VN, Blinov AV. Vitamin D nanocapsulation. Izvestiya Vysshikh Uchebnykh Zavedenii Khimiya Khimicheskaya Tekhnologiya. 2021;64(5):98-105.
  26. Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI, Ruthel G. Ebola virus entry requires the host?programmed recognition of an intracellular receptor. The EMBO journal. 2012;31(8):1947-60.
  27. Mishununa VV, Chapanov MM, Gakaeva KI, Tsoroeva MB, Kazanova SA, Gorlova MI, Blinova AA, Remizova AA, Gvozdenko AA, Golik AB, Remizov D. Computed Quantum Chemical Modeling of the Effect of Nanosilver on Coronavirus COVID-19. Pharmacophore. 2021;12(2).
  28. Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe Jr JE, Saphire EO. Structural basis for Marburg virus neutralization by a cross-reactive human antibody. Cell. 2015;160(5):904-12.
  29. Orsaeva AT, Tamrieva LA, Mischvelov AE, Osadchiy SS, Osipchuk GV, Povetkin SN, Simonov An. Development of a Prototype of a Smart Ward as an Element of a Digital Polyclinic. Pharmacophore. 2020;11(1):142-6.

Other issues:


Call-for-Scientific Papers
Call-for-Research Papers:
ITJEMAST invites you to submit high quality papers for full peer-review and possible publication in areas pertaining engineering, science, management and technology, especially interdisciplinary/cross-disciplinary/multidisciplinary subjects.

To publish your work in the next available issue, your manuscripts together with copyright transfer document signed by all authors can be submitted via email to Editor @ (please see all detail from Instructions for Authors)

Publication and peer-reviewed process:
After the peer-review process, articles will be on-line published in the available next issue. However, the International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies cannot guarantee the exact publication time as the process may take longer time, subject to peer-review approval and adjustment of the submitted articles.