International Transaction Journal of Engineering,
Management, & Applied Sciences & Technologies

FEATURE PEER-REVIEWED ARTICLE

• EVALUATION OF TOXICOLOGICAL PARAMETERS OF DAPS-25K AFTER A SINGLE INTRAGASTIRIC ADMINISTRATION TO MICE AND GUINEA PIGS

  R.O. Vasiliev, E.I. Troshin, S.A. Brevnova, N. Yu. Yugatova (Department of Veterinary Radiobiology and BZHCHS, St. Petersburg State Academy of Veterinary Medicine, St. Petersburg, RUSSIAN FEDERATION),
  A.V. Shishkin (Department of Anatomy and Physiology, Izhevsk State Agricultural Academy, Izhevsk, RUSSIAN FEDERATION),
  I.L. Vasilyeva, A. N. Kulikov (Department of Veterinary Sanitary Expertise and Radiobiology, Izhevsk State Agricultural Academy, Izhevsk, RUSSIAN FEDERATION).
  

  Disciplinary: Veterinary Medicine.

  ➤ FullText

  DOI: 10.14456/ITJEMAST.2020.199

  Keywords: Autopsy of dead animals; Diacetophenonyl selenide; DAPS-25k; Acute toxicity; Experiment mice; Experiment guinea pigs; Intragastric administration; Organic forms of selenium.

  Abstract
  Lack of selenium in food chains contributes to the development of about 40 diseases in animals. In conditions of acute selenium deficiency in agroecosystems, enrichment of plant feed for animals with selenium with the help of food additives is becoming increasingly important. However, inorganic forms of selenium are highly toxic and their use requires strict veterinary control. Therefore, feed additives containing organoselenium compounds are of the greatest interest. One of these additives is DAPS-25k, a new generation organoselenium preparation synthesized by domestic scientists. Thus, this work aimed to determine the parameters of acute toxicity of DAPS-25k after a single intragastric administration to mice and guinea pigs. It was found that high doses (25-50 mg/kg) of DAPS-25k after a single intragastric administration cause a decrease in general body temperature and live weight accompanied with depression and pulmonary edema. Guinea pigs were more sensitive to DAPS-25k, and LD₅₀ in them was 15.8 ± 3.45 mg/kg, and in mice 19.6 ± 4.452 mg/kg.
  
  

  Paper ID: 11A10P

  Cite this article:

  Vasiliev, R.O., Troshin, E.I., Brevnova, S.A., Yugatova, N. Yu., Shishkin, A.V., Vasilyeva, I.L., Kulikov, A.N. (2020). EVALUATION OF TOXICOLOGICAL PARAMETERS OF DAPS-25K AFTER A SINGLE INTRAGASTIRIC ADMINISTRATION TO MICE AND GUINEA PIGS. International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11(10), 11A10P, 1-13.